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Naoki Yoshimura Selected Research

Interstitial Cystitis (Interstitial Cystitis, Chronic)

3/2022Reduction of Bladder Capacity Under Anesthesia Following Multiple Recurrences and Repeated Surgeries of Hunner Lesions in Patients With Interstitial Cystitis.
1/2022The O'Leary-Sant Interstitial Cystitis Symptom Index is a clinically useful indicator of treatment outcome in patients with interstitial cystitis/bladder pain syndrome with Hunner lesions: A post hoc analysis of the Japanese phase III trial of KRP-116D, 50% dimethyl sulfoxide solution.
1/2022Effects of human Muse cells on bladder inflammation, overactivity, and nociception in a chemically induced Hunner-type interstitial cystitis-like rat model.
1/2021Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study.
1/2019Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments.
1/2019Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis/bladder pain syndrome.
5/2018Pharmacological management of interstitial cystitis /bladder pain syndrome and the role cyclosporine and other immunomodulating drugs play.
1/2017Effect of Intravesical Liposome-Based Nerve Growth Factor Antisense Therapy on Bladder Overactivity and Nociception in a Rat Model of Cystitis Induced by Hydrogen Peroxide.
1/2017Intravesical liposome therapy for interstitial cystitis.
1/2016Liposome Based Intravesical Therapy Targeting Nerve Growth Factor Ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis.
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Naoki Yoshimura Research Topics

Disease

38Inflammation (Inflammations)
01/2022 - 01/2002
34Spinal Cord Injuries (Spinal Cord Injury)
06/2022 - 11/2002
28Interstitial Cystitis (Interstitial Cystitis, Chronic)
03/2022 - 01/2002
27Overactive Urinary Bladder (Overactive Bladder)
01/2022 - 11/2002
25Pain (Aches)
03/2022 - 01/2002
23Stress Urinary Incontinence
01/2020 - 12/2003
20Cystitis
01/2022 - 05/2002
18Ulcerative Colitis
04/2022 - 01/2003
16Sneezing
01/2020 - 08/2003
9Neoplasms (Cancer)
01/2022 - 01/2002
9Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
01/2022 - 10/2005
9Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2021 - 10/2005
8Underactive Urinary Bladder
01/2022 - 01/2014
8Crohn Disease (Crohn's Disease)
01/2021 - 08/2014
8Ataxia (Dyssynergia)
01/2021 - 01/2004
8Hemorrhage
08/2020 - 06/2010
8Urinary Bladder Neck Obstruction (Bladder Neck Obstruction)
05/2018 - 04/2006
7Heart Failure
09/2022 - 10/2005
7Fibrosis (Cirrhosis)
06/2022 - 08/2017
6Neurogenic Urinary Bladder (Bladder, Neurogenic)
11/2020 - 08/2003
6Hypersensitivity (Allergy)
01/2019 - 10/2008
6Wounds and Injuries (Trauma)
11/2017 - 10/2007
5Congenital Heart Defects (Congenital Heart Defect)
01/2018 - 05/2003
5Abnormal Reflex (Hyperreflexia)
09/2011 - 11/2002
4Ischemia
12/2021 - 08/2017
4Neuralgia (Stump Neuralgia)
03/2021 - 01/2016
4Hypertrophy
05/2018 - 10/2006
4Body Weight (Weight, Body)
06/2016 - 06/2003
4Parkinson Disease (Parkinson's Disease)
05/2016 - 08/2003
4Infections
01/2015 - 03/2004
4Urinary Bladder Diseases (Bladder Diseases)
01/2014 - 05/2004
4Ventricular Heart Septal Defects (Ventricular Septal Defect)
12/2006 - 12/2002
3Diabetes Mellitus
12/2021 - 09/2002
3Lower Urinary Tract Symptoms
12/2020 - 11/2006
3Colitis
01/2018 - 04/2015

Drug/Important Bio-Agent (IBA)

18Nerve Growth Factor (NGF)IBA
06/2022 - 09/2002
18Messenger RNA (mRNA)IBA
12/2021 - 10/2007
17Pharmaceutical PreparationsIBA
06/2022 - 11/2002
15Capsaicin (Zostrix)FDA Link
01/2019 - 11/2002
14CytokinesIBA
10/2021 - 10/2005
12Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2015 - 05/2004
11Proteins (Proteins, Gene)FDA Link
12/2021 - 01/2002
10salicylhydroxamic acid (SHAM)IBA
01/2017 - 09/2005
9Therapeutic UsesIBA
12/2021 - 02/2008
9Formaldehyde (Formol)FDA Link
01/2021 - 04/2014
9Type A Botulinum Toxins (Botox)FDA Link
01/2017 - 10/2004
7Adrenergic Receptors (Adrenergic Receptor)IBA
01/2020 - 02/2007
6Liposomes (Liposome)IBA
12/2021 - 01/2014
6Biomarkers (Surrogate Marker)IBA
01/2021 - 02/2009
6Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2021 - 01/2017
6Muscarinic AntagonistsIBA
10/2020 - 02/2005
6Tadalafil (Cialis)FDA Link
01/2020 - 10/2014
6ProstaglandinsIBA
11/2019 - 02/2006
6Botulinum Toxins (Botulinum Toxin)IBA
02/2017 - 11/2002
5Cadherins (E-Cadherin)IBA
01/2022 - 01/2019
5Infliximab (Remicade)FDA Link
01/2021 - 05/2013
5CollagenIBA
11/2020 - 08/2017
5Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
01/2017 - 02/2005
5Cholinergic Antagonists (Anticholinergics)IBA
01/2017 - 01/2003
5Acetic Acid (Vinegar)FDA LinkGeneric
12/2016 - 09/2002
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2016 - 09/2004
5Urethane (Ethyl Carbamate)IBA
09/2015 - 08/2003
5EnzymesIBA
03/2015 - 01/2002
4SteroidsIBA
06/2022 - 04/2004
4Antisense OligonucleotidesIBA
12/2021 - 08/2013
4Adalimumab (Humira)FDA Link
01/2021 - 11/2016
4Cholinergic Agents (Cholinergics)IBA
01/2021 - 03/2008
4Interleukin-6 (Interleukin 6)IBA
09/2020 - 04/2014
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2020 - 10/2005
4Phosphodiesterase 5 InhibitorsIBA
01/2020 - 08/2017
42-mercaptopurineIBA
09/2019 - 05/2013
4suplatast tosilateIBA
01/2019 - 05/2002
4resiniferatoxinIBA
01/2018 - 01/2003
4Norepinephrine (Noradrenaline)FDA LinkGeneric
09/2015 - 02/2007
3Adrenal Cortex Hormones (Corticosteroids)IBA
06/2022 - 04/2004
3Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
01/2022 - 01/2014
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 05/2003
3ElastinIBA
11/2020 - 08/2017
3Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2020 - 05/2002
3Streptozocin (Streptozotocin)FDA Link
05/2020 - 09/2002
3Transforming Growth Factor beta (TGF-beta)IBA
01/2020 - 01/2002
3Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
01/2020 - 08/2017
3Adenosine Triphosphate (ATP)IBA
01/2020 - 07/2004
3Dinoprostone (PGE2)FDA Link
11/2019 - 03/2011
3Azathioprine (Imuran)FDA LinkGeneric
09/2019 - 11/2016
3Analgesics (Analgesic Drugs)IBA
03/2019 - 04/2007
3AntibodiesIBA
01/2019 - 11/2002
3ChemokinesIBA
01/2018 - 09/2010
3Serotonin ReceptorsIBA
01/2018 - 07/2008

Therapy/Procedure

47Therapeutics
06/2022 - 05/2002
9Intravesical Administration
01/2022 - 02/2005
8Drug Therapy (Chemotherapy)
07/2021 - 12/2003
7Cardiopulmonary Bypass (Heart-Lung Bypass)
09/2022 - 01/2002
7Thoracotomy
03/2021 - 01/2009
7Blood Component Removal (Apheresis)
11/2020 - 01/2003
5Anesthesia
03/2022 - 12/2006
5Catheters
01/2018 - 08/2003
4Ligation
07/2021 - 05/2008
3Conservative Treatment
08/2020 - 02/2017
3Lasers (Laser)
01/2018 - 04/2015